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RFamide (RFa)‐related peptides modulate pain digesting in the mammalian CNS. However, there is absolutely no correlation in the sensitivity of C‐fibres to RFa peptides, protons and amiloride: 74% of tested RFa‐sensitive C‐fibres had been insensitive to protons and in 67% of cases the response to peptides was insensitive to amiloride.

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